Myc and cell cycle control
نویسندگان
چکیده
منابع مشابه
Myc and the cell cycle.
Ectopic expression of the c-Myc oncoprotein prevents cell cycle arrest in response to growth-inhibitory signals, differentiation stimuli, or mitogen withdrawal. Moreover, Myc activation in quiescent cells is sufficient to induce cell cycle entry in the absence of growth factors. Thus, Myc transduces a potent mitogenic stimulus but, concomitantly, induces apoptosis in the absence of survival fac...
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The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region helix-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization with Max for specific DNA binding. Mad family members are expressed primarily in differentiated tissues where they recruit histone deacetylase complexes via the mSin3 intera...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2015
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2014.03.013